Indocyanine Green for Injection, USP

Indocyanine Green for Injection USP is the leading fluorescence product trusted by physicians, to visualize fluorescence and guide their procedures. Indocyanine Green (ICG) is the gold standard in diagnosing several serious conditions and is a key diagnostic tool used by physicians worldwide.

INDOCYANINE GREEN FOR INJECTION USP A TRICARBOCYANINE DYE, IS INDICATED FOR3:

INDOCYANINE GREEN FOR INJECTION USP (ICG)²,4

KEY FEATURES

Ophthalmology Focus

Diagnostic Green is the leading provider of trusted high quality fluorescence products for physicians worldwide.

Indocyanine Green Angiography (ICGA) is the gold standard in diagnosing a number of serious eye conditions and is a key diagnostic tool used by ophthalmology specialists worldwide. It helps to study the anatomy, physiology, and pathology of choroidal and retinal circulation. It has an important role in the diagnosis of various ocular pathologies¹. ICGA is particularly useful in the differential diagnosis of Polypoidal Choroidal Vasculopathy (PCV), Central Serous Chorioretinopathy (CSCR), and Retinal Angiomatous Proliferation (RAP), which can be misdiagnosed as nAMD (Neovascular Age-related Macular Degeneration)².

VERDYE (INDOCYANINE GREEN)

Verdye (Indocyanine Green (ICG)) is a tricarbocyanine dye with both hydrophilic and lipophilic properties.

The retention of ICG in the fenestrated choroidal circulation, combined with its low permeability, makes ICG angiography ideal for viewing the choroidal blood vessels. Once injected, Verdye binds to plasma proteins and quickly circulates to the choroid layer, delineating the choroidal veins within 15-20 secs.

Verdye is cleared exclusively through the liver and then excreted through the bile. It does not undergo metabolism. Verdye has an excellent safety profile and adverse reactions occur very rarely (<1/10,000). Using ICGA at initial presentation helps identify disorders of the choroidal circulation, allowing differential treatment approaches that may improve outcomes and safety for patients.

VERDYE IS COMMONLY USED FOR

ICG imaging is an essential requirement for specialised retinal clinics at tertiary referral hospital eye services

INDICATIONS FOR ICG ANGIOGRAPHY INCLUDE

ICGA VERSUS OCTA

ICGA and OCTA (Optical Coherence Tomographic Angiography) are useful tools when diagnosing a number of serious eye conditions. Below are some of the advantages of ICGA and limitations associated with OCTA including the determination of accurate visualisation of neovascularisation. In an extensive review of literature in 2023, there was “no evidence found in the literature that OCT-A can replace the classic dye methods” (including ICG)4.
ICGA OCTA
ICGA fluorescence can penetrate blood, fluid and retinal pigment epithelium to reveal underlying abnormalities of the inner choroidal vasculature and is essential for making a definitive diagnosis of PCV. Extremely motion sensitive, requiring a patient to fixate on precise point for several seconds. Patient compliance required, which is often difficult, particularly for older patients.
Excellent visualisation within minutes of the medium & large choroidal vessels. OCTA takes more time than structural scans and requires trade-offs in flow resolution, scan quality and speed.
Wide Field Analysis which is beneficial in the differential diagnosis of PCV, Chronic CSC and RAP. Limited field of view leading to a greater likelihood that lesions may be missed.
ICGA has been shown to optimise detection of capillary macro aneurysms in longstanding diabetic macular edema (DME) or retinal vein occlusion (RVO). Failure to recognise OCTA Projection Artifact (blood vessels seem at erroneous location), may lead to inaccurate clinical assessment.
Information readily available on choroidal vascular leakage. A recent study demonstrated that late leakage in ICGA occurred in all RAP cases4. No information on vascular leakage possible. Image processing for OCTA can alter blood vessel appearance through segmentation defects and image display software can lead to false impressions of vessel location and density.
Duration of ICGA procedure only 15-20mins, very quick analysis. The analysis of these images is time-consuming – may involve many hours of post hoc manual segmentation work, which may be difficult to accommodate during daily medical work routines.
Kinetic analysis of blood flow and flow of liquids. Static only imaging.
In conjunction with fluorescein, global information on all inflammatory diseases achievable. Limited information on limited disease entities.

SEAFORD’S INDOCYANINE GREEN FOR INJECTION USP (ICG) SPECIFICATIONS

PRODUCTIndocyanine Green for Injection USP
PACK SIZEBox of 6 vials of 25 mg of Indocyanine Green Powder for Injection, USP
MEDICINAL
INGREDIENT
Each Vial contains sterile, lyophilized green powder containing 25 mg
lndocyanine Green for Injection, USP
DIN02485796
PRODUCT CODEPICG0025CA
EXPIRY48 MONTHS
AVAILIBILITYOrder from McKesson or Seaford Pharmaceuticals Inc.
No minimum orders required

WHERE TO ORDER

CALL DIRECT

1888.292.3192 OR 905.673.5893

FAX

905.673.5894

EMAIL

ORDERS@SEAFORD.CA

CLINIC AND HOSPITAL USE ONLY

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